Track Vitality Capacity in your Longevity Clinic

Empower your longevity program with objective, functional biomarkers - enabling progress tracking during health interventions.

 

Eforto® brings a new dimension to precise and longevity medicine by making muscle fatigability measurable - enabling quantified progress tracking over time. Through a 5-minute validated effort test, Eforto® generates WHO-recommended biomarkers that reflect core drivers of healthy aging, including resilience, mitochondrial efficiency, and low-grade inflammation.1,2

The Clinical Blind Spot: Why Standard Metrics Miss Reverse Aging

Inflammation and mitochondrial inefficiency often develop silently. Even in apparently fit individuals, subclinical fatigue patterns mark the earliest signs of biological aging and reduced systemic resilience.5

Limitations of current assessment methods:

  • Circulating inflammatory biomarkers (e.g. IL-6 and CRP) fluctuate from day to day and provide only an averaged, indirect snapshot of systemic inflammation. This makes them limited as stand-alone markers in longevity assessment.6,7
  • Peak grip strength values often remain within “normal” ranges even in early biological aging. This masks subtle neuromuscular decline that endurance-based metrics such as grip work and vitality capacity can reveal.2,8,9
  • Conventional clamp-based hydraulic dynamometers, like the Jamar dynamometer, provide only a single peak-force snapshot, offering no insight into the intervention's effect on muscle endurance, recovery capacity, and fatigue over time.8-12 

Longevity clinics lack practical clinical tools to easily track muscle fatigability and vitality over time. This means they miss the opportunity to track the intervention effects.

rehabilitation-therapist-with-notepad-assisting

The Solution: The Eforto® System for Tracking Vitality Capacity and Inflammation

The FDA-registered Eforto® Vigorimeter transforms handgrip testing into a digital biomarker of systemic vitality. By measuring muscle fatigability (grip work) and vitality capacity (Capacity-to-Perceived Vitality ratio), Eforto® detects subtle physiological changes linked to inflammation, mitochondrial efficiency and neuromuscular function.

Read more about the biomarkers
View the clinical evidence
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Key Benefits for Longevity Clinics

Unlike conventional approaches that rely on a static measurement of grip strength, Eforto® captures the dynamic performance of the individual through grip work, reflecting how strength is sustained over time. This dynamic biomarker is more responsive for detecting early changes in intrinsic capacity13. As such, Eforto® provides an early window of opportunity for preventive interventions such as targeted nutrition14-16, allowing for optimization of intrinsic capacity before functional decline becomes clinically significant.
  • Quantification of muscle fatigability17-19
  • Superior sensitivity for changes in inflammation20-22
  • Early detection of decline, before frailty manifests21,7,23
  • Prediction of functional decline before it becomes visible24
  • Fully guided and standardized testing
  • Objective monitoring of physiological recovery and intervention effects
  • Enhanced communication and progress tracking

How Eforto® Works
Pneumatic_measurement_image
Pneumatic measurement

Patients squeeze the ergonomic, rubber bulb - comfortable, painless11,22,25 and suitable for all hand morphologies.12,26
Digital_recording_image
Interactive self-test

Pressure is captured in real time and analyzed for maximal grip strength, endurance, and fatigue slope.
Biomarker_extraction_image
Automatic analysis and benchmarking

Algorithms compute grip work (muscle fatigability) and vitality capacity (Capacity-to-Perceived Vitality ratio), validated biomarkers of subclinical frailty and inflammation.17-22
Dashboard_visualization_reporting_chart
Dashboard visualization and reporting

Clinicians view longitudinal trends, stored securely under HIPAA/GDPR compliance.

Key Clinical Use Cases
6_Early detection of inflammation and frailty
Early detection of inflammation

Detect muscle fatigability decline and functional fatigue before symptoms arise.
7_Personalized resilience profiling
Personalized resilience profiling

Collect baseline fatigability metrics for personalized programs.
8_Monitoring interventions
Monitoring interventions

Follow response to interventions such as exercise and nutrition.
4_Return-to-function documentation
Therapeutic effectiveness documentation

Support therapy milestones and communication with quantitative trends.
5_Tele-rehab monitoring
Remote Therapy Monitoring

Patients perform guided self-tests at home; clinicians review strength trends remotely.
9_Clinical trials and biomarker research
Clinical trials and biomarker research

Collect standardized muscle fatigability data.

Evidence Summary

Eforto® biomarkers (muscle fatigability and vitality capacity) have been validated across aging, inflammation, and rehabilitation contexts and were shown to:

  • Have high reliability compared with hydraulic tools.1,10,11,22,25,27
  • Be comfortable and repeatable even in frail or inflamed hands. 11,22,25-29
  • Be a clinical indicator for energy metabolism, resilience and inflammation (IL-6, TNF-α).17-19
  • Enable early detection of fatigue and sub-clinical frailty. 17

Ready to Bring Vitality Biomarkers into your Longevity Practice with Eforto®?

Eforto® brings biometric precision to longevity care. Move beyond subjective assessment, experience the science of vitality by quantifying the physiology of aging itself.

Detect early inflammatory fatigue, track resilience gains, and document biological vitality over time.

Get your FDA-registered Eforto® M1 Vigorimeter
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Integrate Eforto® Today

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List of References

  1. De Dobbeleer, L., Swart, M.M., Geerds, M.A.J., et al., 2023. Validity and reliability of Eforto®, a system to (self-) monitor grip strength and muscle fatigability in older persons. Aging Clin Exp Res, 35(4), pp.835-845.
  2. Knoop, V., Costenoble, A., Debain, A., et al., 2021. The interrelationship between grip work, self-perceived fatigue and pre-frailty in community-dwelling octogenarians. Exp Gerontol, 152, p.111440.
  3. Cesari, M., Penninx, B.W., Pahor, M., et al., 2004. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci, 59(3), pp.M242-M248.
  4. Soysal, P., Stubbs, B., Lucato, P., et al., 2016. Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Res Rev, 31, pp.1-8.
  5. Bohannon, R.W., 2019. Grip strength: an indispensable biomarker for older adults. Clin Interv Aging, pp.1681-1691.
  6. Picotte, M., Campbell, C.G., Thorland, W.G., 2009. Day-to-day variation in plasma interleukin-6 concentrations in older adults. Cytokine, 47(3), pp.162-165.
  7. Franceschi, C., Garagnani, P., Vitale, G., et al., 2017. Inflammaging and ‘Garb-aging’. Trends Endocrinol Metab, 28(3), pp.199-212.
  8. De Dobbeleer, L., Theou, O., Beyer, I., et al., 2018. Martin Vigorimeter assesses muscle fatigability in older adults better than the Jamar Dynamometer. Exp Gerontol, 111, pp.65-70.
  9. De Dobbeleer, L., Beckwée, D., Arnold, P., et al., 2020. Muscle fatigability measured with Pneumatic and Hydraulic handgrip systems are not interchangeable. Exp Gerontol, 136, p.110950.
  10. Sipers, W.M., Verdijk, L.B., Sipers, S.J., et al., 2016. The Martin vigorimeter represents a reliable and more practical tool than the Jamar dynamometer to assess handgrip strength in the geriatric patient. J Am Med Dir Assoc, 17(5), pp.466-e1.
  11. Bautmans, I., Onyema, O., Van Puyvelde, K., et al., 2011. Grip work estimation during sustained maximal contraction: validity and relationship with dependency and inflammation in elderly persons. J Nutr Health Aging, 15(8), pp.731-736.
  12. Bergeron, V., Kajganic, P., 2024. Pressure Sensors for Evaluating Hand Grasp and Pinch. Sensors, 24(17), p.5768.
  13. Gijzel, S.M., van de Leemput, I.A., Scheffer, M., et al., 2019. Dynamical indicators of resilience in postural balance time series are related to successful aging in high-functioning older adults. J Gerontol A Biol Sci Med Sci, 74(7), pp.1119-1126.
  14. Beard, J.R., Officer, A., De Carvalho, I.A., et al., 2016. The World report on ageing and health: a policy framework for healthy ageing. Lancet, 387(10033), pp.2145-2154.
  15. Coelho-Júnior, H.J., Uchida, M.C., Picca, A., et al., 2021. Evidence-based recommendations for resistance and power training to prevent frailty in community-dwellers. Aging Clin Exp Res, 33(8), pp.2069-2086.
  16. Carvalho, L.P., Pion, C.H., El Hajj Boutros, G., et al., 2019. Effect of a 12-week mixed power training on physical function in dynapenic-obese older men: does severity of dynapenia matter? Aging Clin Exp Res, 31(7), pp.977-984.
  17. Bautmans, I., Knoop, V., Thiyagarajan, J.A., et al., 2022. WHO working definition of vitality capacity for healthy longevity monitoring. Lancet Healthy Longev, 3(11), pp.e789-e796.
  18. Mets, T., Bautmans, I., Njemini, R., et al., 2004. The influence of celecoxib on muscle fatigue resistance and mobility in elderly patients with inflammation. Am J Geriatr Pharmacother, 2(4), pp.230-238.
  19. De Dobbeleer, L., Beyer, I., Njemini, R., et al., 2017. Force-time characteristics during sustained maximal handgrip effort according to age and clinical condition. Exp Gerontol, 98, pp.192-198.
  20. Eldadah, B.A., 2010. Fatigue and fatigability in older adults. PM R, 2(5), pp.406-413.
  21. Bautmans, I., Njemini, R., De Backer, J., et al., 2010. Surgery-induced inflammation in relation to age, muscle endurance, and self-perceived fatigue. J Gerontol A Biol Sci Med Sci, 65(3), pp.266-273.
  22. Coppers, B., Heinrich, S., Bayat, S., et al., 2024. Reduced hand function indicates higher disease activity in patients with rheumatoid and psoriatic arthritis. Ann Rheum Dis, 83, p.1342.
  23. Westenberger, A., Nöhre, M., Brähler, E., et al., 2022. Psychometric properties, factor structure, and German population norms of the multidimensional fatigue inventory (MFI-20). Front Psychiatry, 13, p.1062426.
  24. Knoop, V., Costenoble, A., Debain, A., et al., 2023. Muscle endurance and self-perceived fatigue predict decline in gait speed and activities of daily living after 1-year follow-up: results from the BUTTERFLY study. J Gerontol A Biol Sci Med Sci, 78(8), pp.1402-1409.
  25. Gränicher, P., Maurer, Y., Spörri, J., et al., 2024. Accuracy and reliability of grip strength measurements: a comparative device analysis. J Funct Morphol Kinesiol, 9(4), p.274.
  26. Draak, T.H., Pruppers, M.H., Van Nes, S.I., et al., 2015. Grip strength comparison in immune-mediated neuropathies: Vigorimeter vs. Jamar. J Peripher Nerv Syst, 20(3), pp.269-276.
  27. De Dobbeleer, L., Beckwée, D., Arnold, P., et al., 2023. Comparison between two different handgrip systems and protocols on force reduction in handgrip assessment. Gerontology, 69(10), pp.1245-1254.
  28. Neumann, S., Kwisda, S., Krettek, C., Gaulke, R., 2017. Comparison of the grip strength using the Martin-Vigorimeter and the JAMAR-dynamometer: establishment of normal values. In Vivo, 31(5), pp.917-924.
  29. Lee, J.K., Jung, M., Lee, H.B., et al., 2024. Reliability and validity of the Martin Vigorimeter for grip strength measurement in Korean adults. Clin Orthop Surg, 16(4), p.610.